Season 22
This season centers on the 400th milestone episode, in which CIA agent Stan Smith survives a dangerous mission only to discover that the CIA has already replaced him with a clone when he returns home to find his duplicate living his life. The season also features the return of Francine’s sister Gwen and a chaotic pool incident where Francine takes drastic measures to clear the water.
Episodes
Aw Rats, a Pool Party
The Smiths are having a pool party! Everyone is coming, including Francine's sister and Steve's ex! Wait, is that a dead rat in the pool?
The Flume Flume Room
Stan struggles to appreciate Francine's niche interest in flume rides.
Powering Through
Stan is determined to prove that there's no illness he can't power through, even if it ends up killing him... and everyone else.
Camera Stan
Stan thinks he has what it takes to thrive on reality TV; Klaus gets himself a Klaus.
Idol Threat
The school bully saves Steve's life at the carnival and is celebrated as a local hero by everyone but Steve.
The Treasure of Old Chinatown
Steve and Bah Bah, along with a reluctant Francine, set out to discover an ancient Chinese treasure. Roger becomes an online food influencer.
Reaper Madness
After experiencing a euphoric high from a scary story, Klaus and Hayley band together to search for their next fix.
Dude, You're Getting a Del!
Klaus becomes Snot's father figure to woo Snot's mom. Meanwhile, Hayley opens a cat café and hires Roger's infamous cat persona, Marmalade.
Where the Wild Boars Are
Jeff comes of age with the help of an old man. Roger takes care of a "special" shed.
Dumbston Checks In
Steve and Principal Lewis team up to save the school while Stan seeks out a decent meal.
A Donkey's Shame
Stan and Francine drive to Vegas to confront John Mayer.
400?!
Stan nearly dies on his 400th mission and returns home to realize the CIA's secret clone program has already replaced him.
Tales from the Outer Frontier
In this three-part anthology of self-contained tales, the Smiths take on new roles across the harsh frontier of space, confronting mortality, purpose, and that relentless Mars dust.